New Horizons for the Chromosome Segregation Machinery

Abstract 

Kinetochores are multiprotein structures that are assembled on the centromeric chromatin in order to segregate chromosomes during mitosis. The main purpose of kinetochores is to connect the chromosomes with spindle microtubules. In my talk, I will discuss some of my work on the regulation of microtubule coupling machinery at the kinetochore and describe a serendipitous finding that this evolutionarily ancient mitotic machinery plays a cell division independent function during neuronal morphogenesis.