Immunopeptidomics as discovery tool for clinically relevant antigens

Abstract/bio – Associate Professor Dr. Nicola Ternette specialized in sequencing of HLA-associated peptidomes using nanoflow ultra-performance liquid chromatography tandem mass spectrometry (LC-MS) at the University of Oxford. Since 2015, she is heading the Antigen Discovery Group, and the team is applying this methodology to interrogate antigen presentation in multiple pathogen infection models, solid and haematological cancers, and autoimmune diseases. Her talk will explain how liquid chromatography mass spectrometry (LC-MS) can be used for the discovery of T cell antigens for both prophylactic and therapeutic vaccine development in infectious diseases and cancer, and how immunopeptidomics and a detailed understanding of the HLA gene locus can assist our understanding of genetic associations with drug-directed immune responses.