Seminars

Simon Li (Swedlow Lab)–“The Image Data Repository: a platform for publishing, integrating and mining imaging-derived biological data at scale” Anya Read More

  “Establishing iPS derived neural tissues to study the role of Bod1 in neuronal development and function” Iain Porter (Swedlow Read More

Abstract Most of evolutionary biology and animal behaviour is about sex! Sex is, in part, mediated through proteins and their Read More

Simone Bertolini (Gartner lab) ‘Role of the Spindle Assembly Checkpoint gene bub-3 in DNA damage responss’ Viola Denninger (Tanaka lab)  Read More

Abstract The Transforming Growth Factor b superfamily of cytokines has diverse and pleiotropic roles during development, tissue homeostasis and disease Read More

Tony Ly (Lamond lab)  “Proteomic approaches to study cell cycle regulation” Federico Pelisch (Hay lab)  “Sumoylation/desumoylation cycles regulate meiotic chromosome Read More

Julianty Julianty (Rocha lab)  ‘VHL inhibitor as chemical probe in the hypoxia signalling pathway’ Daniel Mariyappa (van Aalten lab)  ‘What Read More

Yili Yin (Hay Lab)  “The Role of RNF4 in DNA replication and repair”. Harunori Yoshikawa (Lamond lab)   “Ribo-SEC for reproducible Read More

Rosalia Fernandez-Alonso (Findlay lab, MRC-PPU)  “Distinct Brd2-Brd4 functionalities coordinate pluripotent exit with Smad2-dependent lineage specification” Karim Rafie (van Aalten lab) Read More

Dr Jens Januschke, Guest Speaker (CDB)   “How is a neuron made? – Cell fate establishment in the Drosophila nervous system”

  Michael Tatham (RTH lab) “How aspirin made me a better and worse scientist”   Mehmet Gundogdu (DvA lab) “Mutations Read More

Abstract Cohesin is a conserved ring-shaped protein complex that tethers DNA molecules together and, in doing so, plays central roles in the Read More

Abstract Faithful DNA replication is vital to prevent disease-causing mutations, chromosomal aberrations and malignant transformation. Accuracy, however, conflicts with pace Read More

Abstract The majority of cancer cells show chromosomal instability (CIN), a condition in which chromosome missegregation occurs at a high Read More

    Jane Wright (RTH lab) “Regulation of pluripotency and differentiation by SUMO”   Jamie Carrington (JJB lab) “Post-replicative Resolution Read More

Abstract Genome instability resulting from accumulation of DNA lesions is not only a hallmark of cancer but also a driving Read More

Luis Garcia (TT lab) “Is the centromere localisation of Aurora B kinase essential for chromosome b-orientation” and Jimena Druker (SR Read More

Fran Inesta (VC lab) ‘Regulation of CMTR1, the mRNA CAP1 methyltransferase’ and Andrii Gorelik (DVA lab) ‘Expanding the genetic code Read More

Abstract Proper functional balance of the cellular proteome is vital for all living cells. Failure of this balance results in Read More

The vast majority of cytosines in a CG context in the mammalian genome are covalently modified by methylation (mC) or Read More

Hong Zhang State Key Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, P.R. China Hong is Read More

Laura D’Ignazio (SR lab) “Investigating the role of HIF-1β in the regulation of the NF-kB pathway” and Amanda Hughes (TOH Read More

Abstract Binyam Mogessie and Melina Schuh Department of Meiosis, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Read More

Abstract: The vast majority of cytosines in a CG context in the mammalian genome are covalently modified by methylation (mC) Read More

Abstract ES cells and iPS cells are considered to be potential alternative cell sources for the transplantation therapy as well Read More

Alejandro Brenes Murillo (AIL lab) – ‘The Encyclopedia of Proteome Dynamics – A big data ecosystem for (prote)omics’ and Claudia Read More

Debora Pasquali (TT lab) “Dynamics of microtubules and kinetochores in yeast mitosis” and Lin Huang (DL lab) “N6-methylation of adenine Read More

Abstract Chromatin is an extremely large heterogenous macromolecule with many different levels of folding. This presents a number of challenges Read More

Abstract “DNA Encodes RNA, RNA Encodes Protein.” Even 60 years after its postulation, the simple, yet exceptionally powerful central dogma Read More

Ananya Kar (JJB lab) “Alternate single strand binding complex, hSSB-INTS3 complex, can initiate ATR signalling independent of RPA”

Bettina Meier (AG lab) – “Profiling mutational signatures of DNA repair deficiency and carcinogen exposure in C. elegans” and David Read More

Chuan Fu (DvA lab) – title tbc and Villo Muha (DvA lab) – “Too much O-GlcNAc causing trouble”

Abstract Splicing is the process of removing introns from precursor messenger RNAs, joining adjacent exons to produce spliced mRNA. There Read More

Abstract In recent years the field of biological structural electron microscopy has seen an enormous transformation. Cryo-EM is now recognised Read More

GRE internal seminars by Seraina Blumli (TOH lab) – Title: Engineering Cell Lines to Study the Function of the mSWI/SNF Read More

GRE internal seminars by Alex Booth (TT lab) Title: ‘Preventing chromosome scattering during prometaphase’ and Iain Porter (JRS lab) Title: Read More

Peter Gillespie (JJB)- Title: Unlicense to Kill: small molecule inhibition of replication licensing as a novel anti-cancer target and Emma Branigan Read More

Abstract – Repair of DNA breaks by homologous recombination (HR) can lead to the formation of recombination intermediates, which often Read More

Title: What’s new for SLS OMERO Users

Abstract Induced pluripotent stem cell (iPSC) technology holds great promise for both basic research and clinical applications. A critical step Read More

  Andrii Gorelik (DVA lab) ‘Enzymatic incorporation of a stable O-GlcNAc analogue’ and Shuyu Li (TT) ‘Mechanism for the efficient Read More

Taciana Kasciukovic (TT) – Title: ‘Capturing kinetochore architecture in vivo’ and Alison Galloway (VC) – Title: ‘Looking for specificity in the Read More

After a degree in biochemistry from Oxford University, Max obtained his PhD from the Gurdon Institute in Cambridge, studying the Read More

The proteasome is essential in all eukaryotes for the highly regulated ATP dependent proteolysis of ubiquitin-tagged proteins, including key cell Read More

Rajaei Almohammed (VC) – Title: ‘Deciphering the role of the mRNA 5’ cap methyltransferase RNMT in neurons’ and Vanessa Alvarez Read More

Abstract Packing genomic DNA into the eukaryotic cell nucleus is a task similar to stowing the London Underground network in Read More

Abstract The eukaryotic cell cycle coordinates duplication of the genome and segregation of the DNA to maintain genomic stability. Each Read More

Abstract Paola Vagnarelli is doing interesting work to better understand the regulation and function of poorly understood set of protein Read More

Title  – A Systematic Approach to Scientific Data Management        

Paul Murphy (RTH)- Title ‘Substrate recognition by the disordered region of an ubiquitin E3 ligase’ and Jose Mela Da Costa Read More

Abstract The five main histological subtypes of high grade serous ovarian cancer have diverse tissues of origin, different drug sensitivity Read More

Abstract Nico Thoma’s group combines crystallography and cryo-electron microscopy to study large protein complexes that are implicated in human disease.  Read More

Abstract The gene silencing function of heterochromatin is proposed to arise in part from the ability of HP1 proteins to Read More

Abstract  The fertilised egg inherits its nuclear DNA from both parents and its mitochondrial DNA (mtDNA) only from the mother. Read More

Abstract Conjugation of ubiquitin onto proteins generates a degradation signal or exerts degradation-independent regulatory functions. Ubiquitylation is governed by the Read More

Haru Yoshikawa (AIL) – ‘Beyond the polysome and ribosome separation by Size Exclusion Chromatography’ and Adel Ibrahim (RTH) – ‘Antibody-RING Read More

Abstract Alternative splicing (AS) plays critical roles in the control of nervous system development and function and is implicated in Read More

Abstract  Ionising radiation (IR) is the cornerstone for treatment of a number of human cancers, the therapeutic effect of which Read More

Title: Regulation of chromosome behaviour during meiosis

Abstract  Kinetochores are multiprotein structures that are assembled on the centromeric chromatin in order to segregate chromosomes during mitosis. The Read More

Diana Rioz (CA) – Title TBC and Katarzyna Knop (GGS) – Title TBC  

Abstract ATP-dependent chromatin remodeling complexes (remodelers) are abundant chromatin-associated molecular motors that mediate the assembly, sliding, restructuring, or ejection of Read More

Abstract The dual-specificity kinase/ATPase Rio1, which is conserved from archaea to humans, is best known for contributing to pre-rRNA processing Read More

Abstract In >95% of motor neuron disease (MND) the normally nuclear protein TDP-43 exits the nucleus and accumulates as hyperphosphorylated Read More

Abstract: It can be easy to forget that scientists are, at heart, simply curious people who enjoy apply induction to Read More

Ehsan Pourkarimi Molecular Biology Program, Memorial Sloan-Kettering Cancer Center Epigenetic marks are important for the regulation of DNA replication and Read More

Jimena Druker Title: Identification of novel cell cycle PHD-dependent targets and Bettina Meier Title: Mutational signatures of DNA repair deficiency Read More

Abstract Aging has become the major risk factor for human morbidity and mortality. However, a complete understanding of this process Read More

ADP-ribosylation (ADPr) is a key player in many physiological and disease conditions, best known for its role in the maintenance Read More

Meng-Ying Wu Title: The role of SWI/SNF chromatin remodeling complexes in Renal Cell Carcinoma Federico Tinarelli Title: Altered loading of Read More

Diana Rios Szwed Title: Investigating the role of FAM111A in DNA replication Radoslow Lukoszek Title: CMTR1 Phosphorylation and it’s Role

Abstract The dynamic organization of the eukaryotic genome into chromatin is integral to genome regulation. Chromatin structure and dynamics, modulated Read More

Functional genomic and proteomic approaches in models such as the early C. elegans embryo helped uncover conserved molecular machinery involved Read More

Abstract: Genome replication is a stochastic process whereby each cell exhibits different patterns of origin activation and replication fork movement.  Despite Read More

Abstract The discovery of microRNAs (miRNAs) has revolutionised the way in which we view gene expression. In human`s there are Read More

Abstract: Imaging-based spatial genomics can provide unprecedented detail on the cellular architecture of complex tissues. Recent advances enable highly-multiplexed gene Read More

Abstract The ciliopathies are a collection of phenotypically overlapping, rare, debilitating and complex conditions. Cilia are present on most cells Read More

Abstract: Kumar Somyajit currently works as a senior postdoc (Assistant professor) with Prof. Jiri Lukas at the Novo Nordisk Foundation Read More

Abstract New cryo-EM technologies enable to investigate protein structures in the native physiological context of the cell. We use these Read More

Brief Introduction Label free quantification (LFQ) and isobaric labelling quantification (ILQ) are the two most popular quantification workflows in discovery Read More

Abstract: We are applying large-scale electron tomography to analyze the ultrastructural organization of microtubule-based spindles. Recently, we have analyzed the Read More

Abstract Single-cell analyses have revealed extensive intra- and inter-patient cancer heterogeneity, but this is not reflected in histologic stratification that Read More

Short Biography: The long-term goal of my lab is to understand to understand how complex chromatin structures are established and Read More

Abstract The control of gene expression is a complex and extensively regulated process that involves numerous nuclear and cytoplasmic steps. Read More

Abstract: Genetic mutations in the nuclear envelope-localized AAA+ ATPase torsinA cause a spectrum of poorly understood neurological diseases including DYT1 Read More

Biological systems are incredibly complex and they can fail in many different ways to cause disease. This is best illustrated Read More

Carolina Gomez Moreira   Title: Role of CMTR1 regulating T cell differentiation lineages

Jane Wright (CA Lab) Title: Impact of chromatin replication upon pluripotency maintenance Laura Bel Borja (FP Lab) Title: Defining the role of Read More

Roberto Bellelli studied medicine in Naples, and first became interested in DNA replication through an internship in the laboratory of Anindya Read More

Abstract In mammals, the acquisition of the germline from the soma provides the germline with an essential challenge, the necessity Read More

Luis Garcia (TT lab) Title: Is localization of Aurora B at centromeres required for chromosome bi-orientation?   Michael Tatham (RH Read More

Wolf Reik obtained his MD from the University of Hamburg. He did his thesis work with Rudolf Jaenisch, and postdoctoral Read More

Title: Sex Differences in Organ Plasticity Abstract:  Internal organs constantly exchange signals, and can respond with striking anatomical and functional Read More

Biography: Michael Tellier originally studied microbiology at the University Paris VII and Institute Pasteur (group of Prof. Didier Mazel) in Read More

Kasper Rasmussen Title: “Aberrant DNA methylation in gene expression and disease” Harinath Doodhi (TT lab) Title: “Error correction is driven by Read More

Dr. Junfang Song (AG Lab) Title: Expression, purification and characterization of the LEM-3/hANKLE1 nuclease, required for the processing of multiple Read More

Tina graduated from University of Zagreb with a degree in Molecular Biology during which she worked in Ivan Dikic’s lab Read More

Abstract Ubiquitination of proteins regulates a number of key cellular processes including protein degradation, endocytosis, translation, innate immunity and DNA Read More

Olga Murina’s interest in the control of genome stability began while studying for a BSc then an MSc in biology at Read More

Abstract Meiosis I cell divisions are a long and complicated process in mammalian oocytes. Particularly notable, is an extended period Read More

Bio Brian Hendrich received his PhD from Stanford University in 1995 working on X chromosome inactivation with Huntington Willard. In Read More

Title: Investigating the mechanism of RING E3 ligases

Title: Identifying potential substrates of the SUMO specific protease SENP6

Title:  Chromatin restoration and composition in euchromatin and heterochromatin along the cell cycle

Abstract Multicellular organisms have evolved sophisticated networks to regulate gene expression through chemical modifications on chromatin. This layer of epigenetic Read More

Title:  DNA methylation at enhancers – shaping gene expression patterns or passively mirroring transcriptional states

Title: DNA replication dynamics during early S phase; a high resolution mapping of DNA replication in human cells

Title: Acute depletion of the ARID1A subunit of mammalian SWI/SNF complexes reveals EP300 dependent activation and repression of transcription

Abstract Enhancers harbor binding motifs that recruit transcription factors (TFs) for gene activation. While cooperative binding of TFs at enhancers Read More

Abstract Chromatin structure is responsive to changes in gene activity but the mechanisms responsible for this are unclear. Non-coding RNAs Read More

Title:  “mRNA cap methyltransferase RNMT promotes ribosome biogenesis in T cells”

Abstract  Ensuring the right balance of proteins and nucleic acids in the cells of an organism is essential for life. Read More

Title: Characterisation of Malignant Missense Mutations in Chromatin Remodelling ATPases

“Dynamics of MCM loading during the G1 phase”

Title – SUMOylation is required for maintenance of the pluripotent state in human induced pluripotent stem cells (hiPSCs)

Title – Working towards a comprehensive TET2 interactome in haematopoietic cells

Title – Erosion of human X chromosome inactivation causes major remodelling of the iPSC proteome

Abstract –  Title:   Abstract:  DNA and RNA can adopt a variety of secondary structures. Four-stranded G-quadruplex structures (G4s) form Read More

Title : BUB-1 phosphorylation regulates PP2A/B56 localisation in meiosis I

Title : Maintenance of chromatin-based information in cycling cells 

Title – Role of cap methyltransferase CMTR1 in T cell gene expression during lineage differentiation

Title: What do Artificial Intelligence techniques contribute to Life Sciences research and how will that change in the future?

Abstract: Structural organisation of eukaryotic cell is fundamental in health and disease. The cells’ volume can be divided into two distinct Read More

Title: Modelling O-GlcNAc transferase intellectual disability in Drosophila melanogaster.  

Abstract Through the integration of structure-guided and functional proteomic assays we have identified and characterised a protein that encodes both Read More

Title: SUMO specific protease SENP6 protects cells against Laminopathy-like nuclear deformation

Abstract/bio – Associate Professor Dr. Nicola Ternette specialized in sequencing of HLA-associated peptidomes using nanoflow ultra-performance liquid chromatography tandem mass Read More

Title – Establishment of a conditional situation to directly visualise error correction and bi-orientation

Title – The Bromo-Tag: A novel PROTAC-inducible degron system for fast reversible targeted protein degradation.

Abstract: Muzlifah has used functional genomics, comparative biology and more recently single cell RNA sequencing to study human mononuclear phagocytes. In Read More

Title: The role of mRNA capping in stem cells, neural differentiation and neuronal function

The role of DDK and Treslin-MTBP in coordinating replication licensing and pre initiation complex formation during DNA replication initiation

Title: ‘Cyclin A and Cks1 subunits in CDK1 complexes promote proteome-wide phosphorylation of non-canonical sites by CDK1’

Title: How to probe the “true” post-translational modifications (PTMs) using proteomics, starting from the profiling of proline hydroxylation sites

Title – Structural and biochemical characterisation of human SWI/SNF-related chromatin remodelling complexes 

Title – Restoration of chromatin after DNA replication in stem cells and how this is influenced by differentiation

Title – Understanding the role of Arsenic in modulating PML/TRIM19 activity

Title – Characterizing the SPT2 histone chaperone in metazoans

Abstract –  In humans the daily production of billions of new blood cells is supported by a specialized group of Read More

Title ‘Maintenance of euchromatin and heterochromatin in cycling cells’

Title – Reconstitution of sister kinetochores interaction with microtubules to study error correction during mitosis 

Bungo Akiyoshi is a Wellcome Trust Senior Research Fellow at the Department of Biochemistry, University of Oxford. He is interested Read More

Abstract – It is vital that organisms achieve the correct balance between proliferation and quiescence for normal development and in Read More

Title: Exploring the epigenetic basis of pre-leukaemic stem and progenitor cells to promote healthy ageing

Title: What is new in OMERO at SLS?   This seminar will show how OMERO is set up for and Read More

Title: “Structural Biology of the Amino Acid Stress Response in Mesothelioma”

Title: Investigating contraction of perinuclear acto-myosin network and its role in kinetochore-microtubule interaction

Title: “Investigating the roles of PBRM1 and VHL using human iPSC derived kidney organoids and proximal tubule like cells”

Title: Investigating the role of PLK-1 in meiosis I

Title – The role of transcription restart in chromatin restoration following DNA replication

Title: A new step in the PML degradation pathway; Unfolding by p97.

Title: Understanding the temporal control of mitotic chromosome formation by condensin I and II

Title: Ensuring Complete Genome Duplication: The Distinct Dynamics of Replication Licensing in Embryonic & Somatic Cells

Abstract Protein interactions are often associated with changes in a protein’s conformation. Studying this structure-function relationship requires gathering information about Read More

Abstract During his PhD at Trinity College Dublin Gerry worked on understanding fundamental mechanisms of chromatin regulation, with a particular focus on Read More

Abstract  The complexity of living organisms does not scale with the predicted number of protein coding genes. Many factors contribute Read More