Dr Harunori Yoshikawa has been awarded Tenvous Scotland grant in the most recent round of funding.

Dr Yoshikawa, postdoctoral researcher in Professor Angus Lamonds’ lab in the Centre for Gene Regulation and Expression, was awarded a small research grant worth £17k. If successful, the research could identify important new diagnostic biomarkers and potential new therapeutic targets for breast and oesophageal cancer.

Dr Yoshikawa said, “I have worked on a ribosome, a large molecular factory, which translates the information on mRNAs to proteins in cells and tissues in our body. The regulation of translation by ribosomes plays an important role in controlling cell function and biological response mechanisms and is typically dysregulated in disease.”

Dr Yoshikawa continued, “I have recently developed a new method, termed “Ribo Mega-SEC”, which allows the efficient and rapid isolation and characterisation of ribosomes from cells and tissues by Size Exclusion Chromatography (SEC). This project aims to apply our new method to examining the changes in composition of ribosomes as well as the changes in protein expression between healthy tissues and breast and oesophageal cancer tissues. This project is based on the collaboration with Professor Russell Petty in the School of Medicine, who will provide me with access to clinical tissue samples.”