ross-smllDr Ross Fennessy and Prof Tom Owen-Hughes have published a study showing that the positions which nucleosomes occupy are restored within a few minutes of DNA replication.

The rapid alignment to promoters and replication origins appears not to require transcription and is altered when the supply of histones to replication forks is impeded. The rapid re-establishment of nucleosome organisation may help to maintain gene expression through cell division.

Establishment of a promoter-based chromatin architecture on recently replicated DNA can accommodate variable inter-nucleosome spacing