Lamond Lab covers Molecular and Cellular Proteomics March 26, 2013 A paper by researchers at the Lamond Lab is the cover story of this month’s (March 2013) issue of Molecular and Cellular Proteomics. The paper, “Global Subcellular Characterization of Protein Degradation Using Quantitative Proteomics”, describes the identification of a subset of proteins in U2OS cells that are rapidly degraded. Researchers at Lamond Lab have also shown that by separately analysing proteins in different subcellular compartments they could identify proteins as rapidly degraded, which would be missed if only whole cell extracts were analysed. Most significantly they have also been able to demonstrate that inhibiting the proteasome results in a very rapid feedback inhibition of translation. “Global Subcellular Characterization of Protein Degradation Using Quantitative Proteomics”, Mark Larance, Yasmeen Ahmad, Kathryn J. Kirkwood, Tony Ly, and Angus I. Lamond, Mol Cell Proteomics 2013 12: 638-650. View the cover image: http://www.mcponline.org/content/12/3.cover-expansion View the paper: http://www.mcponline.org/content/current
