The 18th Wellcome Trust Centre For Gene Regulation & Expression Principal Investigators Retreat was held at Fernie Castle, Letham, Cupar on Friday 3 December 2010. In spite of the snow and inclement weather across the country, the biannual retreat was well-attended and acknowledged to be a great success. Speakers included Sonia Rocha, Eric Griffis, Geoff Barton, Tom Owen Hughes, Ron Hay and Tomo Tanaka. The days retreat was followed by Dinner at the hotel.